Authors:Sklyarova E.V., Nechepurenko Y.M., Bocharov G.A.
Numerical steady state analysis of the Marchuk-Petrov model of antiviral immune response
Abstract:
The problem of guaranteed computation of all steady states of the Marchuk-Petrov model with fixed values of parameters and analysis of their stability is considered. It is shown that the system of ten nonlinear equations, non-negative solutions of which are steady states, can be reduced to a system of two equations. Region of possible non-negative solutions is analytically localized. An effective technology for computing all non-negative solutions and analyzing their stability is proposed. The obtained results provide a computational basis for the study of chronic forms of viral infections using the Marchuk-Petrov model.